Patents & publications

We are passionate about research. We did a considerable amount of it during our academic careers and we continue to do it. Here you can find out how we convert knowledge into assets in industry, life sciences, and medical imaging.

Newest first

Patents 13

  1. 2026
    M. Roffilli, M. Pesic, M. Neri : "Sistema per determinare, a partire da una corrispondente immagine, le coordinate a valori reali di una corrispondente entità", Italian Patent Application n. 102026000011920, applicant MACGUFFIN SRL
    Industrial MacGuffin
  2. 2019
    M. Roffilli : "Method for estimating measurable properties in a three-dimensional volume of material", EU PCT/IB2019/054072, US Patent Application 17/056,364, applicant BIORETICS SRL
    Industrial
  3. 2018
    M. Roffilli : "Metodo per la stima di proprietà misurabili in un volume tridimensionale di materiale", Italian Patent n. 102018000005488, applicant BIORETICS SRL
    Industrial
  4. 2018
    S. Crociani, E. Prosapio, M. Roffilli : "An apparatus for detecting damaged fruit and vegetable product", WO/2018/002841, applicant SER.MAC SRL
    Industrial
  5. 2017
    M. Roffilli : "A method for automatic search for zones of interest in digital images of biological origin", WO/2017/072685, applicant BIORETICS SRL
    Industrial
  6. 2017
    S. Crociani, E. Prosapio, R. Prosapio,M. Roffilli : "An apparatus for measuring fruit and vegetable products; in particular defective fruit and vegetable products", WO/2017/072693, applicant SER.MAC SRL
    Industrial
  7. 2016
    M. Roffilli : "Metodo per la ricerca automatica di zone di interesse in immagini digitali di prodotti, in particolare alimentati in una rispettiva linea di avanzamento industriale di detti prodotti", Italian Patent n. 102016000067600, applicant BIORETICS SRL
    Industrial
  8. 2015
    M. Roffilli : "Metodo per la ricerca automatica di zone di interesse in immagini digitali di provenienza biologica, Italian Patent n. 102015000066577", applicant BIORETICS SRL
    Industrial
  9. 2007
    M. Roffilli , E. Iampieri, E. Angelini, M. Masotti: “Method and corresponding apparatus for automatically searching for zones of interest in digital images”,Pending European Patent (not maintained) n. 07005457.2-1225, applicant ARCADIA LAB SRL
    Life Sciences/Medical Imaging
  10. 2006
    M. Roffilli , E. Iampieri, E. Angelini, M. Masotti: “Metodo, e relativa apparecchiatura, per la ricerca automatica di zone di interesse in immagini digitali”, Brevetto Italiano n. BO2006A200, applicant ARCADIA LAB SRL
    Life Sciences/Medical Imaging
  11. 2002
    R. Campanini, M. Roffilli , N. Lanconelli: “Method, and corresponding apparatus, for automatic detection of regions of interest in digital images of biological tissue”, US Patent Application 10/231,800, applicant Alma Mater Studiorum Università di Bologna
    Life Sciences/Medical Imaging
  12. 2002
    R. Campanini, M. Roffilli , N. Lanconelli: “Automatic detection of region of interest in digital images of biological tissue”, Pending European Patent n. 02027970.9-2218, applicant University of Bologna
    Life Sciences/Medical Imaging
  13. 2001
    R. Campanini, M. Roffilli , N. Lanconelli: “Metodo, e relativa apparecchiatura, per la ricerca automatica di zone di interesse in immagini digitali di tessuto biologico”, Brevetto Italiano n. BO2001A000763, applicant Alma Mater Studiorum Università di Bologna
    Life Sciences/Medical Imaging

Trademarks 3

  1. 2026
    "GUFFINLINK", Italian Trademark Application n. 302026000082225 (word mark), applicant MACGUFFIN SRL
  2. —
    "BIORETICS", trademark of BIORETICS SRL
  3. —
    "ALIQUIS®", trademark of BIORETICS SRL

Publications 30

  1. 2026

    E. Giacobazzi, P. Orlandi, G. Franchini, F. Muzzini, M. Neri, M. Roffilli, "Towards Faster and More Reliable Image-Based Quality Inspection in the Agri-Food Industry Through Optimized Data Pipelines and Neural Architectures", AgriEngineering 8(7), 264 (2026)

    Industrial/Other
  2. 2025

    M. Pesic, G. Lughi, M. Roffilli, "Intelligenza Artificiale Generativa per Digital Twin Urbanistico partecipato", Bollettino della Società Italiana di Fotogrammetria e Topografia, N. 2 (2025), Numero Speciale Premio "Giovani Autori", pp. 95–102 (2025)

    Industrial/Other
  3. 2025

    G. Nunziata, L. Coraggio, S. Crisci, G. De Gregorio, N. Itaco, M. Neri, M. Roffilli, R. Schiattarella, "Quantum Fuzzy Edge Detection algorithm: an industrial application", 2025 IEEE International Conference on Quantum Artificial Intelligence, https://qai2025.unina.it (2025). We acknowledge the financial support from PNRR MUR Project PE0000013 "Future Artificial Intelligence Research (hereafter FAIR)", funded by the European Union – NextGenerationEU, CUP J13D24000090004

    Industrial/Other
  4. 2024

    M. Pesic, G. Lughi, M. Roffilli, "Intelligenza Artificiale Generativa per Digital Twin Urbanistico partecipato", ASITA 2024, 27th National Conference on Geomatics and Geographic Information, Padova, 9–13 December 2024, pp. 463–470, ISBN 979-12-985355-0-3 (2024)

    Industrial/Other
  5. 2023

    M. Roffilli, F.M. Castelli, E. Flebus, M. Neri, "Recomposition of Parts Into Objects in Industrial Applications", Machine learning and optimization for industry and society, Math 2 Product (M2P), 2023

    Industrial/Other
  6. 2021

    ..., Filippo Maria Castelli, Matteo Roffilli et alii, "A multimodal imaging and analysis pipeline for creating a cellular census of the human cerebral cortex", bioRxiv 2021.10.20.464979 (2021)

    Life Sciences/Medical Imaging
  7. 2021

    ..., Roffilli et alii, "3D sub-cellular reconstruction of human Broca area by means of light-sheet fluorescence microscopy", 7th Annual Brain Initiative Investigators Meeting, Poster 5021, USA (2021)

    Life Sciences/Medical Imaging
  8. 2021

    Costantini, Mazzamuto, Roffilli, Castelli, Neri, Lughi, Simonetto, Laurino, Lazzeri, Pesce, Destrieux, Silvestri, Conti, Guerrini, Pavone, “Large-scale, cell-resolution volumetric mapping allows layer-specific investigation of human brain cytoarchitecture”, Biomedical Optics Express (2021), accepted revised from "A combined pipeline for quantitative analysis of human brain cytoarchitecture", bioRxiv (2020)

    Life Sciences/Medical Imaging
  9. 2020
    Constantini, I., Mazzamuto, G., Roffilli, M., Laurino, A., Castelli, F., Neri, M., Lughi, G., Simonetto, A., Lazzeri, E., Pesce, L., Destrieux, C., Silvestri, L., Conti, V., Guerrini, R., & Pavone, F., "3D reconstruction and analysis of four human brain cortex samples with two-photon fluorescence microscopy", EBRAINS. DOI: 10.25493/SNWB-YQR (2020)
    Datasets
  10. 2020

    Filippo Castelli, Giacomo Mazzamuto, Matteo Roffilli, Irene Costantini, Ludovico Silvestri, Francesco Saverio Pavone, "Semantic Segmentation of Neuronal Bodies in Fluorescence Microscopy Using a 2D+3D CNN Training Strategy with Sparsely Annotated Data", arXiv The Sixth International Conference on Machine Learning, Optimization, and Data Science (2020)

    Life Sciences/Medical Imaging
  11. 2020

    ..., Roffilli et alii, 6th Annual Brain Initiative Investigators Meeting, USA (2020)

    Life Sciences/Medical Imaging
  12. 2020
    "Multimodal Image Analysis and Registration for the Creation of Human Brain Cellular Atlas"
    Life Sciences/Medical Imaging
  13. 2020
    "A multi-modality imaging infrastructure linking histology to MRI"
    Life Sciences/Medical Imaging
  14. 2020
    "A multi-modal image analysis pipeline for cellular typology in the framework of an MRI-based atlas coordinate system of the human cerebral cortex"
    Life Sciences/Medical Imaging
  15. 2020
    "Human brain cell census: sample preparation for multimodal analysis including MRI, OCT, LSFM and cell-type specific stereology"
    Life Sciences/Medical Imaging
  16. 2020
    Vladislav Gavryusev, Luca Pesce, Annunziatina Laurino, Giacomo Mazzamuto, Giuseppe Sancataldo, Marina Scardigli, Matteo Roffilli, Ludovico Silvestri, Irene Costantini, Francesco Pavone, "Swift light sheet volumetric charting of large human brain portions", OSA Biophotonics Congress: Biomedical Optics (BioMed 2020)
    Life Sciences/Medical Imaging
  17. 2020
    Luca Pesce, Annunziatina Laurino, Vladislav Gavryusev, Giacomo Mazzamuto, Giuseppe Sancataldo, Marina Scardigli, Matteo Roffilli, Ludovico Silvestri, Irene Costantini, Francesco Pavone, "Fast volumetric mapping of human brain slices", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260B (21 February 2020); https://doi.org/10.1117/12.2544133
    Life Sciences/Medical Imaging
  18. 2019
    Irene Costantini, Giacomo Mazzamuto, Annunziatina Laurino, Erica Lazzeri, Leonardo Sacconi, Mattia Neri, Andrea Simonetto, M. Roffilli, Ludovico Silvestri, Francesco Pavone, "Three-dimensional analysis of human brain cytoarchitectonics by means of a SWITCH/TDE-combined clearing method", SPIE European Conference, Munich, Session 2:Neurophotonics, 26 June 2019
    Life Sciences/Medical Imaging
  19. 2019
    Giacomo Mazzamuto, Francesco Orsini, Matteo Roffilli,Francesco Pavone, Ludovico Silvestri, "Deep learning strategies for scalable analysis of high-resolution brain imagery", SPIE European Conference, Munich, Neurophotonics, 2019 (https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11076/2527055/Deep-learning-strategies-for-scalable-analysis-of-high-resolution-brain/10.1117/12.2527055.short?SSO=1)
    Life Sciences/Medical Imaging
  20. 2018
    G. Mazzamuto, L. Silvestri, I. Costantini, F. Orsini, M. Roffilli, P. Frasconi, L. Sacconi, and F.S. Pavone, "Software Tools for Efficient Processing of High-Resolution 3D Images of Macroscopic Brain Samples" in Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), OSA Technical Digest (Optical Society of America, 2018), paper JTh3A.64
    Life Sciences/Medical Imaging
  21. 2018
    G. Mazzamuto, L. Silvestri, I. Costantini, F. Orsini, M. Roffilli, P. Frasconi, and F.S. Pavone, "A software pipeline for efficient processing of 3D high-resolution microscopy images of large brain samples", 2nd HBP Student Conference - Transdisciplinary Research Linking Neuroscience, Brain Medicine and Com (HBPSC 2018), Ljubljana, 2018
    Life Sciences/Medical Imaging
  22. 2018
    Mazzamuto G., Costantini I., Neri M.,Roffilli M., Silvestri L., Pavone F.S. "Automatic Segmentation of Neurons in 3D Samples of Human Brain Cortex". In: Sim K., Kaufmann P. (eds) Applications of Evolutionary Computation. EvoApplications 2018. Lecture Notes in Computer Science, vol 10784. Springer,2018
    Life Sciences/Medical Imaging
  23. 2017
    G. Mazzamuto, L. Silvestri, I. Costantini, F. Orsini, M. Roffilli, P. Frasconi, L. Sacconi, and F.S. Pavone, "Software tools for high-throughput stitching and processing of μm-resolution 3D images of brain samples", World 2017 Neuroscience Meeting, Washington D.C., 2017
    Life Sciences/Medical Imaging
  24. 2017
    I. Costantini, L. Silvestri, E. Lazzeri, V. Conti, C. Del Torto, G. Mazzamuto, M. Roffilli, L. Sacconi, R. Guerrini, F. S. Pavone, "Three-dimensional investigation of neuronal layer distribution in human brain cortex", World 2017 Neuroscience Meeting, Washington D.C., 2017
    Life Sciences/Medical Imaging
  25. 2015

    O. Schiaratura, P. Ansaloni, G. Lughi, M. Neri, M. Roffilli, F. Serpi, A. Simonetto: “SoC based pattern recognition for Non Destructive Testing system”, International Workshop on Machine learning, Optimization and big Data (MOD 2015), July 21-23 2015

    Industrial/Other
  26. 2014

    B. Bois, A. Volta, G. Lughi, M. Roffilli…: “GIS, mechanistic modelling and ontology: a performing mix for precision and sustainable viticulture”, Proc. of 37h World Congress of Vine and Wine, Mendoza, Argentina, November 9-14 2014

    Industrial/Other
  27. 2014

    P. Ansaloni, G. Bollini, MC. Nannetti, M. Roffilli: “Realizzazione di un plugin open source per QGIS per il calcolo degli indicatori di VAS del PTPR della Regione Emilia-Romagna”, Proc. of 18a Conferenza Nazionale ASITA – Federazione delle Associazioni Scientifiche per le Informazioni Territoriali e Ambientali, October 2014

    Industrial/Other
  28. 2013
    M.C. Pettenati and M. Roffilli, “A Computer Aided Diagnosis System for Large-scale Digital Pathology”, Proceedings of BIT 6th Annual World Cancer Congress (WCC-2013), Xian, China, May 23-25, 2013
    Life Sciences/Medical Imaging
  29. 2012

    M. Roffilli: “Simulazioni di traffico veicolare e modello radiativo: una interpretazione congiunta”, Proc. of 16a Conferenza Nazionale ASITA – Federazione delle Associazioni Scientifiche per le Informazioni Territoriali e Ambientali, November 2012, ISBN 978-88-903132-7-1

    Industrial/Other
  30. 2012

    E. Cerri and M. Roffilli: “Un sistema quantitativo a supporto delle decisioni per la pianificazione territoriale: il caso Unione dei Comuni del Rubicone”, Proc. of 16a Conferenza Nazionale ASITA – Federazione delle Associazioni Scientifiche per le Informazioni Territoriali e Ambientali, November 2012, ISBN 978-88-903132-7-1

    Industrial/Other

Theses 14

  1. 2025
    Bagnolini , Matteo (2025) Applicazioni Industriali di Vision Transformers: un caso studio in ambito agricolo [Laurea triennale 110 e lode], Università di Bologna, Ingegneria e Scienze Informatiche
    Thesis
  2. 2023
    Sciarrillo , Alessandro (2023) Parallelizzazione su GPU algoritmo Marching Squares per applicazione industriale [Laurea triennale 110 e lode], Università di Bologna, Ingegneria e Scienze Informatiche
    Thesis
  3. 2023
    Orlandi , Pietro (2023) Efficient data augmentation for Convolutional Neural Network training: an Industrial Application [Laurea magistrale 110 e lode], Università di Modena e Reggio Emilia, Corso di Informatica
    Thesis
  4. 2021
    Marzo , Alessandro (2021) Combining Sentinel-1 and Sentinel-2 satellite imagery for land cover classication with convolutional neural networks [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  5. 2020
    Meglioli , Greta (2020) Feature engineering of Convolutional Neural Networks in biological imaging [Laurea magistrale 110 e lode], Università di Modena e Reggio Emilia, Corso di Studio in Matematica
    Thesis
  6. 2020
    Calvanese, Giordano (2020) Volumetric Deep Learning techniques in Oil&Gas exploration [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  7. 2020
    Mariani, Tommaso (2020) Deep Reinforcement Learning for Industrial Applications [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  8. 2019
    Castelli, Filippo Maria (2019) 3D CNN methods in biomedical image segmentation [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  9. 2019
    Camborata, Caterina (2019) Capsule networks: a new approach for brain imaging [Laurea magistrale 110], Università di Bologna, Corso di Studio in Fisica
    Thesis
  10. 2017
    Barnabò, Andrea (2017) Machine learning techniques for mammography applications [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  11. 2016
    Nurrito, Eugenio (2016) Scattering networks: efficient 2D implementation and application to melanoma classification. [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  12. 2016
    Mattia, Carmine (2016) Exploring CNNs: an application study on nuclei recognition task in colon cancer histology images [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  13. 2014
    Neri, Mattia (2014) Segmentazione di immagini mammografiche con convolutional neural networks [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Fisica
    Thesis
  14. 2013
    Ansaloni, Pietro (2013) Analisi di immagini con trasformata Ranklet: ottimizzazioni computazionali su CPU e GPU [Laurea magistrale 110 e lode], Università di Bologna, Corso di Studio in Informatica
    Thesis